The payment receipt and participation certificate will are available for downlload/printout in MyPage from December 1 to 14, 2023.
Registration have ended.
APN2023 Abstract
Registration have started.
Online registration will open on November 10, 2023 (JST).
Deadline is 19:00 November 27 2023 (JST).


APN President

Kyungsoo Park
Yonsei University

Hello everyone.

Welcome to the 2023 APN Annual Symposium. We are delighted to have you here. This symposium marks the fifth since the inaugural event held in 2019, and we extend our heartfelt gratitude to all of you who have supported the symposium's growth over the years.

As the Chair of APN, I have consistently emphasized our organization's primary mission in every symposium's opening address since our inaugural event. As you are aware, this mission is to promote the advancement and expansion of pharmacometrics in the Asian region while fostering networking opportunities.

Despite the challenges faced by emerging organizations, APN has consistently invited speakers from over ten countries each year, starting with our inaugural conference. As the Chair, I take great pride in our efforts over the years, and this year, we continued this tradition by inviting 15 speakers from more than ten countries.

I am very pleased to see that, through the participation of speakers from various Asian countries, the APN Symposium is increasingly establishing itself as a well-deserved pan-Asian conference in the field of pharmacometrics.

This year, following the end of the COVID pandemic, we had initially planned to host the symposium in an offline format. However, due to a proposal from our host country, Japan, this year's event will take place online, and we plan to return to an offline format in Japan next year.

We extend our gratitude to all those who have been involved in preparing for this event, including the APN board members. A special thanks to the members of the Japanese organizing committee, including Professor Yasuhiro Tsuji and Dr. Atsunori Kaibara, for their invaluable contributions.

Furthermore, this year, in collaboration with Professor Surulivelrajan Mallayasamy from Manipal College in India, I co-developed a graduate-level course titled "Special Lectures in Pharmacometrics." This course ran from March to June, spanning 16 weeks, with 3 hours of real-time lectures every Thursday afternoon.

A total of 26 students enrolled in the course, with 21 instructors participating, including 14 from Asia. This collective effort allowed us to fulfill APN's second mission, which is "To provide training opportunities to future pharmacometricians."

APN will continue to develop such educational programs in the future to contribute to the training of future pharmacometricians in the Asian region.

In conclusion, we hope that this symposium has been both informative and enjoyable for all of you who attended. We sincerely ask for your ongoing support and commitment to APN in the future.

Thank you.

APN Chair
Kyungsoo Park

Local organizer

Yasuhiro Tsuji
Laboratory of Clinical Pharmacometrics, Nihon University

Dear Colleagues,

On behalf of the local organizing committee of the 5th Asian Pharmacometrics Network (APN) Symposium 2023, I extend a warm welcome to all of you to this online symposium.

First, I would like to express my gratitude to the APN Council for orchestrating this virtual symposium, our Japanese advisor members, fellow APN council members for their invaluable support in various capacities, and our generous sponsors.

The challenges in the realm of pharmacometrics, particularly those pertaining to individualized administration, are undeniably formidable. To thrive in this pursuit, it is imperative to harness cutting-edge technologies that transcend the conventional boundaries of pharmaceutical science. These include artificial intelligence, real-world data, innovative antibody technologies, liquid biopsies, and multi-omics approaches. APN2023 represents a distinctive event that not only presents a vision of the future of pharmacometrics and individualized dosing, but also illustrates how these innovations can be pragmatically applied in drug development and clinical practice. We will also delve into the potential of these advancements to revolutionize the field of pharmacometrics.

We eagerly anticipate your virtual presence at the symposium scheduled for November 29 and 30th, and 2023. Furthermore, we anticipate an "in-person" gathering the following year in Tokyo.



APN2023 Abstract


APN2023 Abstract
Day 1: November 29, 2023 (Wed) Day 2: November 30, 2023 (Thu)
08:30 – 08:45 Registration
08:45 – 08:55 Opening Remarks
Prof. Kyungsoo Park
–Yonsei University, Korea
APN President

Prof. Yasuhiro Tsuji
–Nihon-University, Japan
Host of APN Annual Meeting 2023/2024
08:55 – 09:00 Day 2 Opening
[08:55 – 09:00]
Prof. Yasuhiro Tsuji
– Nihon-University, Japan
Host of APN Annual Meeting 2023/2024
09:00 – 09:45 Plenary Session
ICH M15 MIDD guideline –
Dr. Iwata Daisuke – PMDA, Japan
Dr. Norisuke Kawai – Pfizer, Japan
Dr. Kenya Nakai – Esai, Japan
[Chair: Dr. Jenny Chien
– Assoc. VP, PK/PD, Eli Lilly, U.S.A.]
[6, 9:00 – 9:45] Dr. Dongwoo Kang
– Teva Pharmaceutical, U.S.A.
Bounded Integer Modeling of Abnormal Involuntary Movement Scale (AIMS) Score in Patients with Tardive Dyskinesia
[Chair: Kyungsoo Park]
09:45 – 10:30 [7, 9:45 – 10:30] Prof. Soyoung Lee
– Seoul National University and Hospital, Seoul National University Graduate School, Korea
Bridging from Preclinical to Clinical in Oncology Drug Development
[Chair: Kyungsoo Park]
10:30 – 10:45 Break
10:45 – 11:30 [1]Philippe Auvaro
– Medical Data Vision Co., Ltd.
Unlocking Insights from Real-World Data in Pharmacometrics
[Chair: Yasuhiro Tsuji]
[8]Prof. Yasuhiro Tsuji
– Nihon-University, Japan
Predictive modeling of linezolid-Induced thrombocytopenia using population pharmacokinetics-pharmacodynamics and machine learning
[Chair: Atsunori Kaibara]
11:30 – 12:15 [2]Ayako Mori, and Kaoru Suzuki
– EPS Corporation
Drug Development Support Applied Pharmacometrics Approach
[Chair: Atsunori Kaibara]
[9] Dr. Sung Kweon Cho
– Ajou University, Korea
Integration of Pharmacogenomics and Pharmacometrics
[Chair: Kyungsoo Park]
12:15 – 13:30 Lunch Break
13:30 – 13:45 Student Sessions
[S-1] Yu-Ting Huang
– National Taiwan University
Physiologically Based Mechanistic Insight into Differential Risk of Valproate Hepatotoxicity between Children and Adults: A Focus on Ontogeny Impact
[Chair: Yunn-Fang Ho]
Student Sessions
[S-5] Sukyong Yoon
– Yonsei University, Korea
Model-informed precision dosing in vancomycin treatment
[Chair: Kyungsoo Park]
13:45 – 14:00 [S-2] Dimas Adhi Pradana
– Universitas Gadjah Mada, Indonesia
Population PKPD of Metformin in Type 2 Diabetes Mellitus patients: Analysis of Sparse Sampling Data
[Chair: Akhmad Kharis Nugroho]
[S-6] FOONG Keng Wah
– Universiti Malaya
PopED for optimal sampling points: A case among perioperative patients
[Chair: Yoke-Lin Lo]
14:00 – 14:15 [S-3] Dr. Janice Goh
– Bioinformatics Institute, A*STAR
Translational predictions of Phase 2a first in human trials for tuberculosis drugs using preclinical in vivo and in vitro data
[Chair: Lai San Tham]
[S-7] Ammara Zamir
– Bahauddin Zikarya University, Pakistan
An In-Depth Examination of Physiologically Based Pharmacokinetic Modeling in the Context of Chronic Kidney Disease: A Comprehensive Review of Existing Models
[Chair: Muhammad Usman]
14:15 – 14:30 [S-4] Austin Tan
– National University of Singapore
Using Phase 1 Glycemic Data in the Evaluation of Two Semi-mechanistic PK/PD Models for Predicting Long-term HbA1c in Type 2 Diabetes
[Chair: Lai San Tham]
[S-8] Dr. Sejung Hwang
– Seoul National University and Hosptial
Evaluation and prediction of drug transporter-mediated drug-drug interactions of methotrexate using physiologically based pharmacokinetic modeling
[Chair: Kyungsoo Park]
14:30 – 14:45 Coffee Break
14:45 – 15:30 [3] Dr. Shamin Mohd Saffian
– Universiti Kebangsaan Malaysia
Population pharmacokinetic model of intravenous immunoglobulin G in patients treated for various immune system disorders
[Chair: Yoke-Lin Lo]
[10] Assoc. Prof. VU Dinh Hoa
– Ha Noi University of Pharmacy, Viet Nam
Development of MIPD for vancomycin
[Chair: TRAN Manh Hung]
15:30 – 16:15 [4] Dr. Guan (Xiaoduo Guan)
– Pharmacometrics, Pfizer China
topic on Clinical Trial Simulation
[Chair: Wei, Hua]
[11] Dr. Subramanian
– Pharmacology department of Certara
Cardiovascular safety assessment:Concentration-QTc assessment in Drug Development
[Chair: Surulivel rajan Mallayasamy]
16:15 – 16:30 Coffee Break
16:30 – 17:15 [5]Sanae Fujita
– ClinChoice, K.K., Tokyo
ClinChoice - as an Asia-centric CRO, overview, and experience in Asia
[Chair: Yasuhiro Tsuji]
[12]Assistant Prof. Swantje Völler
– Leiden University, Netherlands
A framework for evaluating pediatric population PK models
[Chair: Muhammad Usman]
17:15 – 17:30 Closing of Day 1 & Introduction of APN2024
Prof. Yasuhiro Tsuji
– Nihon-University, Japan
Host of APN Annual Meeting 2023/2024
Closing APN2023
Organizing Committee chairperson
Dr. Atsunori Kaibara
– Eli Lilly, Japan
Japan Representative, APN Board


Online registration will open on November 10, 2023 (JST).
On-line Participation Fees apply to payments received prior to the indicated deadlines.


Until 19:00, 27 November 2023 (JST)

Participants member or Non member

JPY 8,000 Japanese Yen


JPY 1,500 Japanese Yen